This is a tough one. No one can answer this question, as not everyone knows the answer.
There are many theories. There is evidence of a positive relationship between insulin and weight. That would imply a positive association between insulin and insulin resistance. But, there is not enough evidence to decide that this relationship is causal. There is evidence of a negative relationship between glucose metabolism and insulin. This has to be tested, but more research is needed.
There is a positive correlation between dieting and weight loss. This means that a person who loses a lot of weight has higher insulin levels; this means that a dieter is already at high insulin levels, so if they diet harder, they cannot lose weight, or at least not as much as if they didn’t diet at all. This also requires the insulin hypothesis to be tested: does having more insulin lead to increased hunger?
The evidence for this theory is not conclusive; some of it comes from observational studies, while others comes from longitudinal studies.
A study published in PLOS One looked at the impact of dieting on obesity from 1999 to 2007. The scientists measured the levels of glucose metabolism in obese and non-obese subjects in several weight-loss programs. The researchers measured insulin and leptin levels. They found that obese subjects who lost 1.7 kg were three times more likely to have reduced insulin production. This was because their insulin concentrations were lower than non-obese subjects. Since they are more likely to have lowered insulin, it is likely the change in their insulin makes them more hungry and puts them in a worse eating pattern.
Another study, conducted in 2012 by researchers from the University of Cambridge and The Hospital for Sick Children, looked at the link between body weight and insulin in children and adults. They looked at the impact of weight loss for children under 16 years of age. It found the lower levels of insulin among obese children and parents, who had lost more than 1.5 kg.
A couple of studies looked at insulin levels in adults and found some support for the insulin hypothesis or the glucose hypothesis. One study published in PLOS One looked at insulin levels when people lost weight from a calorie deficit. It found a reduction in insulin when people lost weight.
Another study looked at the relationship between insulin and weight loss. It found an inverse relationship between insulin and weight loss after 6 months of weight loss. This was supported by another study showing that when people diet successfully, insulin production in people will increase.
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